Play 0:00 Usually no major preparation is needed for a skin biopsy, but some procedures may require patient preparation. The provider will give specific instructions about any preparation needed before the biopsy. Patients should inform their provider about any medical conditions or allergies they may have, and all medications, vitamins, or supplements that they take regularly. Many people want to play an active part in making decisions about their medical care and want to learn all they can about the type of biopsy being performed. It often helps to make a list of questions to ask your provider before the biopsy. To help remember what your provider says, you may want to take notes. You may also want to have a family member or friend with you when you talk to your provider -- to take part in the discussion, to take notes, or just to listen. Although most patients are able to drive themselves home following the procedure, it may be helpful to arrange to have a family member or friend available for support or unforeseen circumstances. Fortunately, most skin biopsies are minor procedures that can be accomplished quickly during an office visit.